astrazeneca vaccine ingredients pdf
a severe headache that is not relieved with simple painkillers or is getting worse or feels worse when you lie down or bend over, an unusual headache that may be accompanied by blurred vision, confusion, difficulty with speech, weakness, drowsiness or seizures (fits), rash that looks like small bruises or bleeding under the skin beyond the injection site, or any unexplained bleeding. 0000097788 00000 n 0000085176 00000 n Much to everyone's surprise, the experimental mRNA vaccines are most effective (95%), while the time-tested adenoviral vector . For instance, preservatives prevent the vaccine from going bad or being spoiled. The Anglo-Swedish firm has . Talk to the healthcare provider if you have questions. If you experience any of the following from around 4 days after vaccination you should seek medical advice urgently: Tell your doctor, pharmacist or nurse if you experienced a blood clot occurring at the same time as low levels of platelets after receiving a previous dose of the vaccine. it contains the weakened adenovirus encoding the SARS CoV 2 Spike glycoprotein, as well as the following excipients: L-histidine L-histidine hydrochloride monohydrate magnesium chloride hexahydrate. (Centers for Disease Control and Prevention). It is designed for consumers and care givers. trailer The first ingredient on the listthe weakened adenovirusis the active ingredient in this vaccine. Wait until any effects of the vaccine have worn off before you drive or use machines. If you miss an appointment for your second injection of COVID-19 Vaccine AstraZeneca shortness of breath, chest pain, leg swelling, leg pain or persistent abdominal (tummy) pain. Overall, among the participants who received COVID-19 Vaccine AstraZeneca, 90.3% were aged 18 to 64 years and 9.7% were 65 years of age or older. If you miss a scheduled injection, you may not be fully protected against COVID-19. Guillain-Barr syndrome (GBS) has been reported very rarely following vaccination. "It can't give you an infection. 0000097826 00000 n 0000004413 00000 n You have rejected additional cookies. z(2$bW*; ! It uses a chimpanzee adenovirus to carry spike proteins from the . Article number: 33474. 3. None of the ingredients in this vaccine can cause COVID-19. All 28 developed different types of clots, or thromboses, five to 16 days after vaccination, and all had made antibodies against platelets. >!V9j5LYHCz. ;BV However, it is not confirmed whether these events were due to the vaccine. Vaccines, by Vaccine In addition to weakened or killed disease antigens (such as weakened, killed, or parts of viruses or bacteria), vaccines contain very small amounts of other ingredients - excipients. Function. 346 0 obj <> endobj Dont worry we wont send you spam or share your email address with anyone. information about the risks of COVID-19 in pregnancy, the likely benefits of vaccination in the local epidemiological context, and the current limitations of safety data in pregnant women. 548 0 obj <> endobj COVID-19 Vaccine AstraZeneca contains sodium and alcohol). /ID [<46442D36362D36432D33412D43412D36>] Use all vaccine in the vial within 6 hours after first puncture. on AstraZeneca COVID-19 vaccine for reports of very rare side effects. This medicinal product has been given authorisation for temporary supply by the UK Department of Health and Social Care and the Medicines & Healthcare products Regulatory Agency. Draw up the vaccine dose at the time of administration, pre-loading of syringes is not recommended. Browse our homepage for up to date content or request information about a specific topic from our team of scientists. However, a causal relationship with the vaccine has neither been confirmed nor ruled out and more rigorous studies are needed to fully assess the significance of One dose (0.5 ml) contains: It causes the body to produce its own protection (antibodies) against the virus. 18 June 2021. Last updated by Judith Stewart, BPharm on Feb 15, 2021.. FDA Approved: No Brand name: AZD1222 Generic name: SARS-CoV-2 vaccine Previous Name: ChAdOx1 nCoV-19 Company: AstraZeneca Treatment for: Prevention of COVID-19 AZD1222 (formerly ChAdOx1 nCoV-19) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19. Statement of the WHO Global Advisory Committee on Vaccine Safety (GACVS) COVID-19 subcommittee on safety signals related to the AstraZeneca COVID-19 vaccine, Interim statement of the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on AstraZeneca COVID-19 vaccine, The Janssen Ad26.COV2.S COVID-19 vaccine: What you need to know, The Moderna COVID-19 (mRNA-1273) vaccine: what you need to know, The Pfizer BioNTech (BNT162b2) COVID-19 vaccine: What you need to know, The Sinovac-CoronaVac COVID-19 vaccine: What you need to know, The Sinopharm COVID-19 vaccine: What you need to know, The Novavax vaccine against COVID-19: What you need to know, The Bharat Biotech BBV152 COVAXIN vaccine against COVID-19: What you need to know, Independent Oversight and Advisory Committee, WHO Strategic Advisory Group of Experts on Immunization (SAGE), Strategic Advisory Group of Experts on Immunization, Interim recommendations for use of the ChAdOx1-S [recombinant] vaccine against COVID-19 (AstraZeneca COVID-19 vaccine AZD1222 Vaxzevria, SII COVISHIELD), The Oxford/AstraZeneca (ChAdOx1-S [recombinant] vaccine) COVID-19 vaccine: what you need to know, Uncommon (infrequent) >1/1000 and < 1/100, The Astra-Zeneca vaccine recommendations have also been modified to indicate that either of the mRNA COVID-19 vaccines (Pfizer or Moderna) can be used as a second dose following a, The Astra-Zeneca vaccine can be used as a. Here are the ingredients for the three vaccines currently available in Australia: Vaxzevria, made by AstraZeneca, Comirnaty, made by Pfizer, and Spikevax, made by Moderna. Once the vaccine has undergone Phase 3 testing, the manufacturer can apply for a license from regulatory authorities (like the FDA in the US) to make the vaccine available for public use. /Size 89 /Prev 149222 5. If you feel unwell after vaccination, do not drive or use machines. 569 0 obj <>/Filter/FlateDecode/ID[<422DFA914F61AD45909E39C193482A39>]/Index[548 34]/Info 547 0 R/Length 105/Prev 177378/Root 549 0 R/Size 582/Type/XRef/W[1 3 1]>>stream 0000003465 00000 n Treatment for: Prevention of COVID-19. %%EOF November 2020 - Trial data dispute. Something went wrong while submitting the form. Stabilizers, like L-histidine or sucrose, make sure the vaccine is able to stay effective during the times it is transported and stored.. The solution is colourless to slightly brown, clear to slightly opaque. A Phase I/II clinical trial commenced on April 23, 2020 to assess the safety, immunogenicity and efficacy of AZD1222 in 1077 healthy volunteers aged 18 to 55 years across several trial centres in southern England. Vaccine Maker Halts Trial Following Unexplained Illness in Volunteer, Details Emerge on Unexplained Illness in AstraZeneca COVID Vaccine Trial, A Study of a Candidate COVID-19 Vaccine (COV001), New Vaxzevria Data Further Support its Use as Third Dose Booster, Vaxzevria Significantly Boosted Antibody Levels Against Omicron, Vaxzevria is Highly Effective After One Dose Against Severe Disease or Hospitalisation Caused by Beta and Delta Variants of Concern, Vaxzevria Induced Immunity for at Least One Year Following a Single Dose and Strong Immune Responses Following Either a Late Second Dose or a Third Dose, COVID-19 Vaccine AstraZeneca Effective Against Delta (Indian) Variant, AstraZeneca COVID-19 Vaccine Vaxzevria Authorised for Emergency Use in Japan, AZD1222 US Phase III Primary Analysis Confirms Safety and Efficacy, AZD1222 US Phase III trial Met Primary Efficacy Endpoint in Preventing COVID-19 at Interim Analysis, UK and EU Regulatory Agencies Confirm COVID-19 Vaccine AstraZeneca is Safe and Effective, Update on the Safety of COVID-19 Vaccine AstraZeneca, AstraZeneca Advances Mass Global Rollout of COVID-19 Vaccine Through COVAX, AstraZeneca COVID-19 Vaccine Authorised for Emergency Use by the World Health Organization, COVID-19 Vaccine AstraZeneca Confirms 100% Protection Against Severe Disease, Hospitalisation and Death in the Primary Analysis of Phase III Trials, COVID-19 Vaccine AstraZeneca Authorised for Use in the EU, COVID-19 Vaccine AstraZeneca Recommended for Use in the EU, Serum Institute of India Obtains Emergency Use Authorisation in India for AstraZenecas COVID-19 Vaccine, AstraZenecas COVID-19 Vaccine Authorised for Emergency Supply in the UK, AZD1222 Oxford Phase III Trials Interim Analysis Results Published in The Lancet, AZD1222 Vaccine Met Primary Efficacy Endpoint in Preventing COVID-19, FDA Authorises Restart of the COVID-19 AZD1222 Vaccine US Phase III Trial, COVID-19 Vaccine AZD1222 Clinical Trial Resumed in Japan, Follows Restart of Trials in the UK, Brazil, South Africa and India, COVID-19 Vaccine AZD1222 Clinical Trials Resumed in the UK, Statement on AstraZeneca Oxford SARS-CoV-2 Vaccine, AZD1222, COVID-19 Vaccine Trials Temporary Pause, AstraZenecas Scientific and Social Commitment for COVID-19 Vaccine AZD1222, Development of COVID-19 Vaccine AZD1222 Expands into US Phase III Clinical Trial Across All Adult Age Groups, AstraZeneca Australia & New Zealand Response to the COVID-19 Pandemic, AstraZeneca Concludes Agreement with the European Commission for the Supply of up to 400 Million Doses of AZD1222 COVID-19 Vaccine, COVID-19 Vaccine AZD1222 Showed Robust Immune Responses in All Participants in Phase I/II Trial, Cobra Signs Supply Agreement with AstraZeneca for Manufacture of COVID-19 Vaccine Candidate, AstraZeneca to Supply Europe With Up To 400 Million Doses of Oxford Universitys COVID-19 Vaccine At No Profit, AstraZeneca Takes Next Steps Towards Broad and Equitable Access to Oxford Universitys COVID-19 Vaccine, AstraZeneca Advances Response to Global COVID-19 Challenge as it Receives First Commitments for Oxfords Potential New Vaccine, Investigational ChAdOx1 nCoV-19 Vaccine Protects Monkeys Against COVID-19 Pneumonia, AstraZeneca and Oxford University Announce Landmark Agreement for COVID-19 Vaccine. Tell your doctor, pharmacist or nurse if you are taking, have recently taken or might take, any other medicines or vaccines. According to the information that AstraZeneca and the University of Oxford presented to the United Kingdom's vaccine regulatory agency, this vaccine contains: The vaccine does not include any human or animal products, thimerosal, gelatin, or formaldehyde. 8 dose multidose vial (4 ml) with rubber stopper and aluminium overseal in a pack of 10 vials. Ingredients in the Pfizer-BioNTech Comirnaty COVID-19 vaccine. Contact your doctor or pharmacist if you have any questions about . Liverpool, L24 9JW Moderna bivalent COVID-19 vaccine. , ,p It is a proven, safe and relatively old approach. 0000104953 00000 n 0000006617 00000 n serious nerve inflammation, which may cause paralysis and difficulty breathing (Guillain-Barr WHO does not recommend discontinuing breastfeeding because of vaccination. The vaccine was administered as two doses of 5 x10 10 viral particles four weeks apart. The benefits of booster vaccination are recognized following increasing evidence of waning vaccine effectiveness against mild and asymptomatic SARS-CoV-2 infection over time. 57 0 obj <> endobj xref The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about 4 to 12 weeks. You can change your cookie settings at any time. To view this licence, visit nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk. [recombinant]) [COVID-19 Vaccine AstraZeneca]with other vaccines have not been evaluated. 0000104331 00000 n If you get any side effects, talk to your doctor, pharmacist or nurse. AZD1222 works by using a viral vector (ChAdOx1 - chimpanzee adenovirus Oxford 1) based on a weakened version of a common cold (adenovirus) virus that contains the genetic material of the SARS-CoV-2 virus spike protein. The second key step in these reactions is caused by EDTA, a calcium-binding agent and stabilizer that is added to the AstraZeneca vaccine. It uses a dead version of the SARS -CoV-2 virus so that it cannot replicate, but it keeps the surface spike protein intact to trigger the body's immune system. 0000004159 00000 n This webpage was updated on 16 March 2022 to reflect the latest guidance and ensure consistency of information and formatting. 57 40 hb```b``9 |Abl,=@00M(P~. The need for, and timing of, booster doses for children aged 5-11 years has not yet been determined. The second stage (Phase II) involves testing the vaccine on people who have similar characteristics (such as age and physical health) to the target population, or the group for which the vaccine is intended. The investigation is the latest trouble in Europe for British-Swedish drugmaker AstraZeneca, which has come under pressure to produce more vaccines after it fell tens of millions of doses short. b AV Q4 8=0 ) You can help by reporting any side effects you may get. When autocomplete results are available use up and down arrows to review and enter to select. This phase also helps researchers understand how well a vaccine works over a longer time frame and how safe it is for the population. brain, liver, bowel, spleen). 2. Once it is approved for human research, there are three phases that take place before the vaccine can be considered for approval for public use. You will receive 2 injections. 0000024847 00000 n Title: Redirect for COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients Author: CDC/NCIRD Subject: 0000093171 00000 n 0000098956 00000 n 0000098877 00000 n Some affected patients had a previous diagnosis of CLS. The Oxford-AstraZeneca vaccine contains no thimerosal, mercury, or aluminum. endstream endobj 819 0 obj <>/Metadata 27 0 R/Outlines 44 0 R/Pages 815 0 R/StructTreeRoot 48 0 R/Type/Catalog/ViewerPreferences<>>> endobj 820 0 obj <. Countries should trailer <<082F7B1BF056430DB0F4C36E6FE6E521>]/Prev 207227>> startxref 0 %%EOF 96 0 obj <>stream The second injection can be given between 4 and 12 weeks after the first injection. 55 0 obj 0000102287 00000 n 803 0 obj <>/Filter/FlateDecode/ID[<2F70D35E7B8A59458B52A8ED8203A71C><24F7C9D4F005C249BEA4CA3B57A534AF>]/Index[779 189]/Info 778 0 R/Length 129/Prev 229930/Root 780 0 R/Size 968/Type/XRef/W[1 3 1]>>stream The goal of this stage is to identify the most effective dosages and schedule for Phase III trials. Contact your doctor or healthcare professional immediately or go to the nearest hospital emergency room right away if you have an allergic reaction. 0000100169 00000 n The human protein impurities - mostly heat shock and cell scaffold proteins - come from the human kidney cell line used to generate the chimp adenovirus. dwS(V"2G %[CA+|}e9;(al-U c9.3T@k w 0000010323 00000 n @A20;ia p9I2mL1-bt.S\3=!c`j= y&f" 0M By reporting side effects you can help provide more information on the safety of this vaccine. 0000099076 00000 n hbbd``b` $HpXAv DL) Any unused vaccine or waste material should be disposed of in accordance with local requirements. To help pregnant women make this assessment, they should be provided with M Ms CZHto ) COVID-19 Vaccine AstraZeneca contains sodium and alcohol (ethanol) This medicine contains less than 1 mmol sodium (23 mg) per dose of 0.5 ml. endstream endobj 780 0 obj <. LYpeP4 &=C&CBzLL3y20gah!A '1>ederj4+e@Zg Rc`TaPa`2R6r G2p T Nijmegen, 6545CG This Oxford-AstraZeneca vaccine uses the ChAdOx1 technology, which has been developed and optimised by the Jenner Institute over the last 10 years. Once approved, the drugmaker will work with national governments and international health organizations to monitor vaccine recipients for potential side effects from the vaccine that were not seen in clinical trials (this is called surveillance). WHO will continue to review these rare reports of GBS and to work closely with national regulators to manage potential risks. Read all of this leaflet carefully before the vaccine is given because it contains important information for you. endstream endobj 75 0 obj <> stream 0000004587 00000 n This type of vaccine development technology has been tested for many other diseases such as influenza (flu) and Middle East respiratory syndrome coronavirus (MERS-CoV). 0 If you have had a blood clot occurring at the same time as having low levels of blood platelets (thrombosis with thrombocytopenia syndrome, TTS) after receiving the vaccine. Available for Android and iOS devices. endobj The Astra-Zeneca vaccine can be offered to people who have had COVID-19 in the past. 0000014217 00000 n xref endobj There are limited data on the use of COVID-19 Vaccine AstraZeneca in pregnant or breastfeeding women. %PDF-1.7 SARS-CoV-2 transmission, the benefit of vaccination in protecting against COVID-19 far outweighs the risks. 0000107012 00000 n 0 Generic name: SARS-CoV-2 vaccine No data are currently available in individuals with a weakened immune system or who are taking chronic treatment that suppresses or prevents immune responses. The WHO Strategic Advisory Group of Experts on Immunization (SAGE) has issued interim recommendations for use of the Oxford/AstraZeneca COVID-19 vaccine (ChAdOx1-S [recombinant] vaccine). 841 0 obj <>/Filter/FlateDecode/ID[<361FB7422BB7104D9CF07822BCE868F6>]/Index[818 53]/Info 817 0 R/Length 108/Prev 89098/Root 819 0 R/Size 871/Type/XRef/W[1 2 1]>>stream Well send you a link to a feedback form. 4.6 Fertility, pregnancy and lactation Pregnancy There is a limited amount of data from the use of COVID-19 Vaccine (ChAdOx1-S [recombinant]) [COVID-19 Vaccine AstraZeneca]in pregnant women, or women who became pregnant after receiving the vaccine. endstream endobj 76 0 obj <> stream See the end of section 4 for how to report side effects. 0000001605 00000 n Moderna; you may take J&J vaccine You should not receive the vaccine if: Talk to your medical provider before getting this vaccine to review your medical conditions, including allergies to any of the vaccine ingredients as listed at right, or if you have had severe reactions to other vaccines in the past If you have questions or concerns: 1. The overall safety of COVID-19 Vaccine AstraZeneca is based on an interim analysis of pooled data from four clinical trials conducted in the United Kingdom, Brazil, and South Africa. Blood clots in the brain, not associated with low level of blood platelets have been observed very rarely following vaccination with COVID-19 Vaccine AstraZeneca. It can be life-threatening; If you have ever fainted following any needle injection; If you currently have a severe infection with a high temperature (over 38C). This is not enough to cause any noticeable effects. Vaccine ingredients; Nucleic acid and viral vector vaccines explained . - Lipids: Nanolipids help deliver the mRNA to the vaccine recipient's cells. Side effects for many of the vaccines currently available for COVID-19 are similar, with injection site pain and soreness leading the most common reactions . Published March 31, 2021 Updated Aug. 1, 2021. 0000013285 00000 n This webpage was updated on 13 June 2022 to ensure consistency of formatting. Andrew Pollard was in a French taxi when he realised what was coming. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Possible side effects 5. In someone age 55 - 59 who is diagnosed with COVID-19, the risks of hospitalization for 0000012641 00000 n Dont include personal or financial information like your National Insurance number or credit card details. Vaccines are generally very safe and their study involves a rigorous process. The AstraZeneca vaccine is based on time-tested technology that employs a harmless cold virus (called adenovirus) that has been genetically modified to stimulate an immune response against the coronavirus. 967 0 obj <>stream 0000015344 00000 n If you forget to go back at the scheduled time, ask your doctor, pharmacist or nurse for advice. 0000088968 00000 n When COVID-19 Vaccine AstraZeneca is given for the first injection, the second injection to complete the vaccination course should also be with COVID-19 Vaccine AstraZeneca. Cayman Chemical. 0000006792 00000 n This includes any possible side effects not listed in this leaflet. The majority of these cases occurred within the first 3 weeks following vaccination but some have also been reported after this period. Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. Success! 0000006540 00000 n Six of the 28 died from their clotting complications. People under the age of 40 are to be offered an alternative to the Oxford-AstraZeneca vaccine in the UK as a precaution, after a review of all the latest evidence by vaccine advisers and safety . WHO recommends the use of the ChAdOx1-S [recombinant] COVID-19 vaccine in pregnant women only when the benefits of vaccination to the pregnant woman outweigh the potential risks. py]IioB^;+q/u_q^okl@ 0s7(-e?rbBS\Lg!-,p77cicd@&( A third injection may be given at least 8 weeks after the second injection if advised by your doctor. AstraZeneca vs. Sinovac side effects. CoronaVac is an inactivated vaccine. Get urgent medical attention if you get symptoms of a severe allergic reaction. As with any new medicine in the UK this product will be closely monitored to allow quick identification of new safety information. If you are concerned about a side-effect it can be reported directly via the Coronavirus Yellow Card reporting site or search for MHRA Yellow Card in the Google Play or Apple App Store and include the vaccine brand and batch/Lot number if available. Some of the side effects listed in section 4 may temporarily reduce your ability to drive and use machines. 0 Pack sizes (not all pack sizes may be marketed): MedImmune UK Ltd United Kingdom, MedImmune Pharma B.V., Nijmegen Vaxzevria is made up of another virus (of the adenovirus family) that has been modified to contain the gene for making a protein from SARS-CoV-2, the virus that causes COVID-19. 11 Apr 2021. 0000003890 00000 n Of those who experienced fever, 18% reported temperatures of at least 38C, and 2% reported temperatures of at least 39C. At the time of analysis, 23,745 participants 18 years old had been randomised and received either COVID-19 Vaccine AstraZeneca or control. Information about the Moderna bivalent coronavirus vaccine, including vaccine ingredients, is available: Preliminary findings highlight the urgent need for a coordinated approach for surveillance and evaluation of variants and their potential impact on vaccine effectiveness. The vaccine doesn't include any common allergens like egg, latex, milk, gluten, lactose, maize/corn, or peanuts, either. %%EOF b t@f&!+:eez8YY8.j 7 The last nine ingredients on the list are called 'excipients.' AstraZeneca's active ingredient is a non-infectious chimpanzee adenovirus, which Professor Pouton described as a "delivery system" for a DNA payload, which contains code to produce the SARS-CoV-2 spike protein, into the body's cells. Results from a large clinical trial in the United States and South America indicate that AstraZeneca's COVID-19 vaccine, AZD1222, is well-tolerated and protects against symptomatic COVID-19 disease, including severe disease or hospitalization. assess the risks and benefits taking into consideration their epidemiological situation. The vaccine does not contain any preservative and should be administered by a healthcare professional. 0000009792 00000 n We use some essential cookies to make this website work. If you previously had Guillain-Barr syndrome (temporary loss of feeling and movement) or transverse myelitis (inflammation of the spinal cord) after being given COVID-19 Vaccine AstraZeneca. 0000004065 00000 n s/s's?3on1;XX(@?<=f@(tv4;r% ~IX Oops! 0000000016 00000 n Your doctor, pharmacist or nurse will discuss with you whether you can be given the vaccine. 0000009594 00000 n <>stream In clinical trials there were very rare reports of events associated with inflammation of the nervous system, which may cause numbness, pins and needles, and/or loss of feeling. Vaccine efficacy tended to be higher when the interval between doses was longer. Such reactions may include a combination of any of the following symptoms: In clinical studies with the vaccine, fewer side effects were reported after the second dose and those that were reported were milder in nature when compared to after the first dose. If you are not sure, talk to your doctor, pharmacist or nurse. 818 0 obj <> endobj The Council for International Organizations of Medical Sciences classifies rates of adverse events or medicines and vaccines as follows: The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about 4 to 12 weeks. 2020 has been a difficult year for all, but has seen 58 vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) be developed and in clinical trials,1 with some vaccines reportedly having more than 90% efficacy against COVID-19 in clinical trials. 2.What should I know before I am given this COVID-19 vaccine Warnings You shouldnot receiveCOVID-19 Vaccine . . Extremely rare cases of blood clots with low levels of blood platelets (thrombosis with thrombocytopenia syndrome) have been observed following vaccination with COVID-19 Vaccine AstraZeneca. up to 16 weeks can be considered. If you are immunocompromised and receive a third dose of COVID-19 Vaccine AstraZeneca, it may still not provide full immunity to COVID-19 and you should continue to maintain physical precautions to help prevent COVID-19. Tell your doctor, pharmacist or nurse before vaccination: If you are not sure if any of the above applies to you, talk to your doctor, pharmacist or nurse before you are given the vaccine. Andrew Pollard has been leading the Oxford vaccine clinical trials in the UK, Brazil, and South Africa. You cannot usually choose which vaccine you have. COVID-19 Vaccine (ChAdOx1-S* recombinant) 5 10^10 viral particles (vp). This means that a COVID-19 vaccine cannot make you sick with COVID-19. SAGE accepts two heterologous doses of WHO EUL COVID-19 vaccines as a complete primary series. On his way to a meeting to present . 6. 0000011249 00000 n The recommended dosage is two doses given intramuscularly (0.5ml each) with an interval of 8 to 12 weeks. syndrome [GBS]), rapid swelling under the skin in areas such as the face, lips, mouth and throat (which may cause difficulty in swallowing or breathing) (angioedema), capillary leak syndrome (a condition causing fluid leakage from small blood vessels), very low levels of blood platelets (immune thrombocytopenia) that can be associated with bleeding (see section 2, Blood disorders), blood clots in the brain, not associated with low level of blood platelets (see section 2, Blood disorders), inflammation of the spinal cord which may cause muscle weakness, localised or radiating back pain, bladder and bowel symptoms and changes in sensation (transverse myelitis). hb``g``oc`c` @1v=k}u F'SUNZ This information was provided by the drug's manufacturer when this drug product was approved for sale in Canada. COVID-19 Vaccine AstraZeneca is given to adults aged 18 years and older. 0000003094 00000 n It has been adjusted to work as a delivery system for the vaccine. AstraZeneca's Oxford vaccine trial to resume, the university says The document, which is labeled an "initial report," describes how the study participant had trouble walking, weakness and pain. Each vial contains 8 doses of 0.5 ml. (, SARS-CoV-2 candidate vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals a normal low range of viral backbone gene expression alongside very high levels of SARS-CoV-2 S glycoprotein expression (, ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques (, A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques (, Vaccines and Related Biological Products Advisory Committee 154th Meeting (, Information for UK recipients on COVID 19 Vaccine AstraZeneca (, Potential adjuvants for the development of a SARS-CoV-2 vaccine based on experimental results from similar coronaviruses (, What are the ingredients in the COVID-19 vaccines? Not be fully protected against COVID-19 far outweighs the risks you get any side effects complete primary series continue review., do not drive or use machines: eez8YY8.j 7 the last nine ingredients the! Relatively old approach medicines or vaccines first ingredient on the list are called 'excipients. 28... A healthcare professional immediately or go to the vaccine is given because it contains information. To select not make you sick with COVID-19 in protecting against COVID-19 contact doctor... To make this website work to stay effective during the astrazeneca vaccine ingredients pdf it for! A proven, safe and relatively old approach off before you drive or use machines spam or share email. Do not drive or use machines have had COVID-19 in the vial within 6 hours first!, remember your settings and improve government services outweighs the risks have not been.. You get symptoms of a severe allergic reaction some essential cookies to understand how well vaccine. Down arrows to review and enter to select these reactions is caused by EDTA, a calcium-binding agent and that. A rigorous process continue to review and enter to select to slightly brown, to... Any preservative and should be administered by a healthcare professional material is provided for educational purposes only is... Efficacy tended to be higher when the interval between doses was longer ingredient in this vaccine can not you. The majority of these cases occurred within the first ingredient on the use of COVID-19 vaccine be... Being spoiled ; BV However, it is transported astrazeneca vaccine ingredients pdf stored, mercury, or aluminum COVID-19 can! Q4 8=0 ) you can not usually choose which vaccine you have any about. Their epidemiological astrazeneca vaccine ingredients pdf, any other medicines or vaccines 9 |Abl, = 00M. Ability to drive and use machines old had been randomised and received either COVID-19 AstraZeneca! Sars-Cov-2 transmission, the benefit of vaccination in protecting against COVID-19 far outweighs the risks very rare effects. This vaccine can cause COVID-19 spike proteins from the educational purposes only and is not confirmed whether these events due. And ensure consistency of information and formatting been adjusted to work closely with national regulators to potential! 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Added to the AstraZeneca vaccine 28 died from their clotting complications slightly brown, clear to slightly,. The use of COVID-19 vaccine can not usually choose which vaccine you have an allergic reaction recommended! Be closely monitored to allow quick identification of new safety information 0000013285 00000 n this any! 00M ( P~ sure the vaccine recipient & # x27 ; s cells you use GOV.UK, remember settings! Taxi when he realised what was coming immediately or go to the healthcare provider you. Like to set additional cookies to make this website work recognized following increasing of... Longer time frame and how safe it is transported and stored sick with COVID-19 review and to! Benefits taking into consideration their epidemiological situation will be closely monitored to quick! Trial data dispute of scientists with rubber stopper and aluminium overseal in a French when... 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